Abstract
Retinal Degenerations: Genetics, Mechanisms, and Therapies
Highlights
Several advances have been made in developing therapeutic strategies to treat retinal degenerations, and the success of these approaches to restore vision in patients with retinal degeneration may depend on the functional integrity of retinal ganglion cells
Margolis and Detwiler “Cellular Origin of Spontaneous Ganglion Cell Spike Activity in Animal Models of Retinitis Pigmentosa” demonstrate ganglion cell spike discharge occurs in the absence of photoreceptors and explain the cellular origin of this activity
Loss of photoreceptors in retinal degeneration can alter the synaptic activity of ganglion cells and understanding this phenomenon is critical for developing successful therapies for retinal degenerations
Summary
Several advances have been made in developing therapeutic strategies to treat retinal degenerations, and the success of these approaches to restore vision in patients with retinal degeneration may depend on the functional integrity of retinal ganglion cells. The cumulative results from genetic research and treatment protocols tested on cell and animal models have improved our understanding of pathobiology of inherited and degenerative eye diseases, and have lead to the development of a broad range of potential strategies to treat these conditions.
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