Abstract
Thirteen carbonyl derivatives of imidazo [2,1- c ][1,2,4]triazine have been synthesized as a new bioactive set of substances. Investigations of chromatographic retention with use of mobile phases containing different concentrations of modifier enable derivation of several characteristics indicative of lipophilicity differences among the compounds. The lipophilicity ( R MW ) of the solutes was determined by reversed-phase thin-layer chromatography (RPTLC) with aqueous mobile-phases containing organic modifiers (methanol or dioxane) on water-wettable octadecyl silica. Reversed-phase high-performance liquid chromatography (RP HPLC) systems with aqueous mobile phases and different organic modifiers (methanol, dioxane, acetonitrile, tetrahydrofuran) on octadecyl silica columns was also used for determination of the lipophilicity (log k w ) of the thirteen derivatives. Correlations between ϕ 0 (MeOH) values and ϕ 0 (modifier) were established for all the compounds with high values of correlation coefficients ( ...
Published Version
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