Abstract
In the course of screening natural products for antibacterial activities, a total acetone extract of the seed cake of Paeonia rockii showed significant effects against bacterial strains. Bioactivity-guided fractionation of the EtOAc-soluble fraction of the total acetone extract resulted in the isolation and identification of five resveratrol trimers, including rockiiol C (1), gnetin H (2), suffruticosol A (3), suffruticosol B (4) and suffruticosol C (5). The relative configuration of these compounds was elucidated mainly by comprehensive 1D and 2D-NMR experiments. Compound 1 was a new compound. All isolated compounds exhibited strong antibacterial activities against Gram-positive bacteria.
Highlights
Paeonia rockii subsp. rockii cv “spp.” (Paeoniaceae) is a shrub widely distributed in China
In the course of screening natural products for antibacterial activities, it was found that the acetone extract from the seed cake of P. rockii had significant inhibitory effects on bacterial strains
The EtOAc-soluble fraction of the acetone extract from the seed cake of P. rockii was separated by silica-gel, gel permeation chromatography and pre-HPLC (ODS-A) to give one new resveratrol trimer, rockiiol C (1), and four known compounds (2–5) (Figure 1)
Summary
Paeonia rockii subsp. rockii cv “spp.” (Paeoniaceae) is a shrub widely distributed in China. The seed cake is the major by-product in the preparation procedure of crushing cooking oil from the seeds of Paeonia rockii. Molecules 2014, 19 found regarding the chemical constituents of the seed cake of P. rockii, studies on the seeds of other. In the course of screening natural products for antibacterial activities, it was found that the acetone extract from the seed cake of P. rockii had significant inhibitory effects on bacterial strains. Further bioactivity-guided fractionation led to the isolation and identification of one new resveratrol trimer, rockiiol C (1), together with the four known ones. We mainly describe the isolation and structural elucidation of the new resveratrol trimer on the basis of various 2D-NMR techniques, including HSQC, HMBC, 1H-1H COSY and NOESY experiments
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
