Resveratrol protects against physical fatigue and improves exercise performance in mice.

Ruei-Er Wu,Chen-Chung Liao,Wen-Ching Huang,Nai-Wen Kan,Yu-Kai Chang,Chi-Chang Huang

doi:10.3390/molecules18044689

Abstract

Resveratrol (RES) is a well-known phytocompound and food component which has antioxidative and multifunctional bioactivities. However, there is limited evidence for the effects of RES on physical fatigue and exercise performance. The purpose of this study was to evaluate the potential beneficial effects of trans-RES on fatigue and ergogenic functions following physiological challenge. Male ICR mice from four groups (n = 8 per group) were orally administered RES for 21 days at 0, 25, 50, and 125 mg/kg/day, which were respectively designated the vehicle, RES-25, RES-50, and RES-125 groups. The anti-fatigue activity and exercise performance were evaluated using forelimb grip strength, exhaustive swimming time, and levels of serum lactate, ammonia, glucose, and creatine kinase (CK) after a 15-min swimming exercise. The exhaustive swimming time of the RES-25 group (24.72 ± 7.35 min) was significantly (p = 0.0179) longer than that of vehicle group (10.83 ± 1.15 min). A trend analysis revealed that RES treatments increased the grip strength. RES supplementation also produced dose-dependent decreases in serum lactate and ammonia levels and CK activity and also an increase in glucose levels in dose-dependent manners after the 15-min swimming test. The mechanism was related to the increased energy utilization (as blood glucose), and decreased serum levels of lactate, ammonia, and CK. Therefore, RES could be a potential agent with an anti-fatigue pharmacological effect.

Highlights

Resveratrol (RES, trans-3,4',5-trihydroxystilbene), which belongs to the stilbene class of polyphenolic compounds, is produced by plants in response to pathogen infection and a variety of stress conditions, such as climate alteration, and exposure to ozone, heavy metals, and sunlight [1,2].RES is found in many plant species, including berries, grapes, peanuts, pines, etc
Because we observed a significant increase in cumulative food intake in RES-fed mice, the effects of RES on the Body Weight (BW) and fat mass gain were of primary interest
Consistent with the food intake data in the RES-50 and RES-125 groups, we found the BWs of RES-50 and RES-125 groups were significant higher at weeks 2 and 3 compared to the vehicle group (Figure 1)

Summary

Introduction

Resveratrol (RES, trans-3,4',5-trihydroxystilbene), which belongs to the stilbene class of polyphenolic compounds, is produced by plants in response to pathogen infection and a variety of stress conditions, such as climate alteration, and exposure to ozone, heavy metals, and sunlight [1,2].RES is found in many plant species, including berries, grapes, peanuts, pines, etc. Glycosylation is known to protect a compound from degradation and make it more stable, soluble, and absorbed from the gastrointestinal tract [4]. After oral administration, it can be metabolized by liver phase II drug-metabolizing enzymes into such water-soluble forms as RES-3-Oglucuronide and RES-3-O-sulfate. It can be metabolized by liver phase II drug-metabolizing enzymes into such water-soluble forms as RES-3-Oglucuronide and RES-3-O-sulfate These metabolites are the predominant forms excreted in the urine and show a higher serum half-life compared to the parent compound, RES [5]. The absorption of RES is much more efficient by oral administration than other known polyphenols, such as quercetin and catechin [7]

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