Abstract
Type 2 diabetes mellitus (T2DM) is the most common metabolic disease. High glucose-induced macrovascular disease and microangiopathy are major complications of diabetes. E2F3, a member of the E2F transcription factor family, is closely related to cardiovascular diseases. Resveratrol, a nonflavonoid polyphenolic compound widely found in plants, has been shown to have cardiovascular protection. However, there are few studies on whether resveratrol can effectively treat diabetic angiopathy, and the specific mechanism involved needs further study. This study investigated whether E2F3 transcription factors are involved in the process of vascular endothelial injury induced by high glucose and observed its effects on the proliferation of vascular endothelial cells. Then, it analyzed whether resveratrol can inhibit high glucose-induced vascular endothelial cell injury by regulating the E2F3 pathway. We demonstrated that the expression level of the E2F3 transcription factor was significantly inhibited in high glucose state. Resveratrol inhibited high glucose-induced vascular endothelial cell injury by upregulating the E2F3 pathway. High glucose can induce vascular endothelial injury by inhibiting E2F3 gene expression, while resveratrol can inhibit high glucose-induced vascular endothelial injury by activating the E2F3 pathway.
Highlights
Type 2 diabetes mellitus (T2DM), the most common metabolic disease, is mainly caused by islet β-cell dysfunction and insulin resistance [1]
The CCK8 experiment showed that high glucose inhibited cell proliferation (Figure 2)
Our study found for the first time that E2F3 was inhibited in high-glucose states, suggesting that the E2F3 transcription factor pathway may play an important role in diabetic angiopathy
Summary
Type 2 diabetes mellitus (T2DM), the most common metabolic disease, is mainly caused by islet β-cell dysfunction and insulin resistance [1]. With the improvement of living standards and lifestyle changes, the prevalence of T2DM has been increasing year by year and has become a worldwide epidemic disease, and there are currently more than 400 million T2DM patients worldwide [1]. T2DM occurs in a younger population, and more and more adolescents are beginning to suffer from T2DM [2]. The current hypoglycemic drugs and methods for diabetes have made great progress, these treatments are not effective in reducing the risk of diabetic vascular complications [3]. In addition to active hypoglycemic and lipid-lowering and blood pressure control, there is currently no drug that can effectively prevent or treat diabetic complications
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