Abstract
BackgroundIn neonatal rats, MK-801 treatment generates schizophrenia-like symptoms. Resveratrol (RSV) is a phenolic compound and a potent neuroprotective agent. This research aimed to illustrate the effect of RSV on the amelioration of MK-801-induced cognitive and motor impairments in a neonatal rat schizophrenia model and the related potential molecular changes.MethodsRats were administrated with MK-801, MK-801 + RSV (40 mg/kg), or MK-801 + RSV (80 mg/kg). Motor learning, coordination, locomotor and exploratory activity, and spatial memory were measured by rotarod test, pen field test, and Morris water maze test. Relative protein levels were analyzed by Western blot and ELISA. mRNA levels were shown by qRT-PCR.ResultsIn the hippocampus of MK-801-induced schizophrenia rat model, RSV enhanced silent information regulator 1 (SIRT1) and brain derived neurotrophic factor (BDNF) expression and alleviated oxidative stress. Motor perturbations and learning impairments by MK-801 treatment were ameliorated by the administration of RSV.ConclusionIn conclusion, RSV showed neuroprotective effect on MK-801-induced schizophrenia rat model through regulating SIRT1 and downstream BDNF expression in the hippocampus.
Highlights
As a mental disorder, schizophrenia has a lifetime prevalence of 0.3–0.66% throughout the world [1]
Animals were divided into four groups: [1] control group; [2] MK-801 (1 mg/kg) group; [3] MK-801 (1 mg/kg) and RSV (40 mg/kg) group; and [4] MK-801 (1 mg/kg) and RSV
We observed that the treatment of 80 mg/kg resveratrol had no effects on the cognitive and motor functions of rats
Summary
Schizophrenia has a lifetime prevalence of 0.3–0.66% throughout the world [1]. Patients with schizophrenia manifest several cognitive symptoms, including decreased memory, decreased attention and reasoning skills [3]. The incidence of schizophrenia increases during adolescence and the peak age of schizophrenia onset is from 15 to 30 years [4]. Approximately 20% of individuals suffer the disorder before. Role of Resveratrol in Cognitive and Motor Impairments. 18 years old [5]. This research aimed to illustrate the effect of RSV on the amelioration of MK-801induced cognitive and motor impairments in a neonatal rat schizophrenia model and the related potential molecular changes
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