Abstract
BackgroundMeasures of aortic occlusion (AO) for resuscitation in patients with severe torso trauma remain controversial. Our aim was to characterize the current use of resuscitative endovascular balloon occlusion of the aorta (REBOA) and resuscitative open aortic cross-clamping (ACC), and to evaluate whether REBOA should be an alternative method to resuscitative open ACC.MethodsThis study was a retrospective cohort study between 2004 and 2013 from a nationwide trauma registry in Japan. Participants were selected who underwent either REBOA or ACC. Their characteristics, interventions, and outcomes were analyzed to compare REBOA and ACC directly. The primary outcome was in-hospital mortality and the secondary outcome was mortality in the emergency department. Logistic regression analysis was performed to compare the outcomes between REBOA and ACC with adjustment for severity; 1:1 propensity score matching was also performed.ResultsOf the 159,157 trauma patients, 903 were eligible based on the selection criteria. Overall, 405/607 patients (67%) who had REBOA died compared to 210/233 patients (90%) who had ACC. Patients with REBOA had higher revised trauma score (RTS) (mean ± SD, 5.2 ± 2.0 vs. 4.2 ± 2.2; P < 0.001) but higher Injury Severity Score (ISS) (median (interquartile); 34 (25) vs. 34 (20); P < 0.001), and higher probability of survival (0.43 ± 0.36 vs. 0.27 ± 0.30; P < 0.001) compared to those with ACC. REBOA had an odds ratio (OR) for in-hospital mortality of 0.309 (95% confidence interval (CI) = 0.190–0.502) adjusting for trauma and injury severity score using a logistic regression model (n = 903). Similar associations were observed adjusting for RTS (OR = 0.224; 95% CI = 0.129–0.700) or adjusting for ISS (OR, 0.188; 95% CI, 0.116 to 0.303). In the propensity score-matched cohort (n = 304), REBOA was associated with lower mortality compared to ACC (OR, 0.261; 95% CI, 0.130 to 0.523). Patients with REBOA had less severe chest complications than those with ACC (Abbreviated Injury Scale thorax, 3.8 ± 0.8 vs. 4.2 ± 0.8; P < 0.001), although physiological severity and backgrounds were similar in this population.ConclusionsPatients who underwent AO had a high mortality. REBOA might be a favorable alternative method to resuscitative ACC for severe torso trauma although some indication bias could still remain. Further studies are needed to elucidate optimal indications.
Highlights
Measures of aortic occlusion (AO) for resuscitation in patients with severe torso trauma remain controversial
Our aim was to analyze the present situation of resuscitative endovascular balloon occlusion of the aorta (REBOA) and aortic cross-clamping (ACC) usage with nationwide trauma registry data and to evaluate as to whether or not REBOA should be deemed a preferential alternative to resuscitative ACC
2032 patients with trauma were included in this study because they received REBOA or ACC
Summary
Measures of aortic occlusion (AO) for resuscitation in patients with severe torso trauma remain controversial. REBOA has been previously described as useful for hemorrhagic shock in cases of ruptured abdominal aortic aneurysm [2], gastrointestinal bleeding [3], and in postpartum hemorrhage [4] As they are useful in solving multiple problems, endovascular approaches such as trans-catheter arterial embolization (TAE) should become more widely used in trauma settings. There are a few reports to show favorable outcomes of REBOA compared with ACC [1] but no concrete indications of REBOA or ACC efficacy exist at the time of this report To this end, our aim was to analyze the present situation of REBOA and ACC usage with nationwide trauma registry data and to evaluate as to whether or not REBOA should be deemed a preferential alternative to resuscitative ACC
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