Results of the Epidemiology of Diabetes Interventions and Complications Trial.

Abstract

Article A. Writing Team for the DCCT/EDIC Research Group. Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: the Epidemiology of Diabetes Interventions and Complications (EDIC) study. JAMA 2003;290;2159–2167 Article B. Writing Team for the DCCT/EDIC Research Group. Association between 7 years of intensive treatment of type 1 diabetes and long-term mortality. JAMA 2015;313:45–53 The results of the Epidemiology of Diabetes Interventions and Complications (EDIC) study are in, and the results are very interesting. Historically, type 1 diabetes was associated with an increased risk of early or premature mortality compared with the general population. In the pre-insulin era, 50% of patients died within the first 20 months of diagnosis. After the discovery of insulin in 1922, patients with diabetes lived longer. However, they still had a 20-year reduction in life expectancy compared with the general population. In the second half of the 20th century and the beginning of the 21st century, advances have narrowed the survival gap to <4 years. EDIC, the long-term observational follow-up of the Diabetes Control and Complications Trial (DCCT) (1), has sought to help us understand the key factors that have contributed to narrowing this gap. ### Design and Methods The DCCT was …