Results of pre-registration studies of the vaccine against Strangles of horses

Abstract

Horse breeding in Yakutia is associated with year-round grazing and tebenevok keeping of horses. In herd horse breeding, the most common infectious disease is Strangles horses. In the republic, the incidence of Strangles from the total number of young horses is 57.8-62.7%, mortality - 4.0-22.0%. An effective method of combating this infection is vaccination. Based on this, we have developed a new inactivated vaccine against Strangles horses with an immunomodulator, made from the bacterial strain Str. equi "H-5/1", as an immunomodulator added centrate strain of bacteria Bac. subtilis TNP-3. Preclinical trials on laboratory animals (white mice, rabbits) showed that the vaccine protects up to 90% of white mice from experimental infection with a pathogenic strain of mytaceous streptococcus. According to the results of clinical observation, pathoanatomical autopsy, histological examination, it was established that the vaccine does not negatively affect the general condition of animals, does not have allergenic properties, does not cause pathological changes in organs and tissues, and does not have a toxic effect on the body of laboratory animals. Clinical trials were carried out on foals 6-8 months of age. The efficiency of immunization was 97.6%. With the introduction of the development in a separate farm, the economic effect per head will be 3.99 thousand rubles, per 1 ruble of costs - 6.65 rubles. In general, the republic will receive an economic effect in the amount of 49 million 356 thousand rubles. Thus, the method of specific prevention of Strangles horses developed by us is environmentally safe, highly immunogenic and cost-effective. Scientific and technical documentation and the vaccine against myta successfully passed the examination of the VGNKI of veterinary drugs. The vaccine is registered in the register of medicinal products for veterinary use (Rosselkhoznadzor of the Russian Federation) under registration number No. 71-1-27.21-4828 No. PVR-1-27.21/03691 dated 08.12.2021.