Abstract
The paper presents the results of preclinical studies of the allergenic properties of a new drug bisphenol-5, which has pronounced anti-radical activity. An experimental study of the antioxidant was carried out in doses of 2, 5, 20 mg/kg in guinea pigs and rabbits. It was shown that bisphenol-5 is not able to cause a general anaphylaxis reaction (anaphylactic shock). By the method of skin applications, the absence of allergenic effects of the drug in animals was found. During the formulation of conjunctival tests in experimental and control animals, signs of hypersensitivity, both immediate and delayed, were not observed with respect to the test drug. Changes in body temperature, pulse rate, and the number of respiratory movements as a result of clinical studies of the state of the animal organism after applying bisphenol-5 were also not recorded. Thus, the drug Besphenol-5 in the studied doses and under the selected experimental conditions does not have a negative effect on the body of laboratory animals and does not have allergenic properties.
Highlights
The need to intensify the production of livestock products is associated with a regular population growth and an increasing need for good nutrition of people [1]
The increase in animal productivity greatly depends on good nutrition, which affects the quality and nutrition of the main products of livestock farming [4, 5]
The anaphylactogenic effect of the antioxidant preparation bisphenol-5 was studied in general anaphylaxis reactions in guinea pigs
Summary
The need to intensify the production of livestock products is associated with a regular population growth and an increasing need for good nutrition of people [1]. The increase in animal productivity greatly depends on good nutrition, which affects the quality and nutrition of the main products of livestock farming [4, 5]. In modern conditions of agro-industrial complexes, the lack of feed and their low quality, unbalanced diets, poor living conditions of animals lead to a decrease in their adaptive capacities, which causes diseases associated with metabolic disorders develop [3, 6]. Antioxidants being a specific group of compounds of various nature, whose mechanism of action is associated with a slowdown of redox processes in a macroorganism by binding free radicals (reactive oxygen species) are used to eliminate the above consequences in the animals growth technology [7]. The use of antioxidant preparations prevents oxidative processes in feeds [10], which, in turn, leads to the efficient use of feed nutrients and reduce their costs per unit of production
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