Abstract
In case of combined pharmacotherapy, between drugs can occur interactions, which can be dangerous to the life and health of patients. Such combinations of drugs are considered to be one of the serious clinical problems, and are considered as errors that can be prevented. Therefore, it is relevant to determine the frequency of such appointments for further work on their prevention. Aim of the research. Determine the structure and prevalence of the appointments of potentially dangerous combinations of drugs in the treatment of patients under inpatient treatment for further optimization of pharmacotherapy. Materials and methods. In the automated mode, the lists of medical appointments of patients who were under inpatient treatment of 30 health facilities of Zhytomyr region in 2017 were monitored for the purpose of the simultaneous use of drugs, the interaction of which is dangerous. For further analysis by the levels of clinical significance using the Drug Interaction Checker system, the "Major" (hazardous) and "Moderate" (significant) combinations were selected on the Internet resource www.drugs.com. The frequency of the appointments of dangerous combinations, their prevalence by the nosological classes and the profiles of the offices of medical institutions was determined. Results. As a result of the monitoring of 69405 cases, it was found that the average number of prescriptions per patient was 5.6±1.2 titles. In 1390 cases of treatment (2.0 % of 69405) simultaneously prescribed medicines, the interaction of which could be dangerous. In the structure of dangerous combinations, 81.5 % is taken with the simultaneous administration of drugs containing active substances ketorolac and pentoxifylline. The frequency of potentially dangerous appointments was greatest in the treatment of patients with diseases of the blood and blood-forming organs (D50-D89) – 11.6 %, in diseases of the musculoskeletal system and connective tissue (M00-M99) – 7.7 %, in diseases of the nervous system – 5.0 % of all cases of treatment.
Highlights
When providing medical care doctors often use a combination of drugs
As a result of the monitoring, 69405 electronic sheets of appointments of patients who received inpatient care in hospitals in Zhytomyr region during 2017 determined that 389 INN drugs were used in general, the average number of medical appointments was 5.6±1.2 preparations per one the patient
After checking through the Drug Interaction Checker system, the online resource www.drugs.com refers to the 1282 combinations (92.2 %) to the Major group, and to the Moderate group 108 (7.8 %) (Table 1)
Summary
PHARMACOTHERAPY UNDER INPATIENT the prevention of such cases, as they are hazardous to the life and health of patients. To analyze the structure and prevalence several illnesses in the patient. TREATMENT of the appointments of potentially (which is more typical for older people), as well as the inadequate efficacy or safety of monotherapy. At the same time, according to research results, combined administration of drugs sharply increases the risk of side effects [1, 2]. Introduction of 2 drugs leads to adverse drug reactions (ADR) due to interactions between drugs in 6 % of patients, and the use of 5 drugs increases. Serhii Hryshchuk PhD, Senior Lecturer Department of medical and biological basics of physical training and sports Zhytomyr Ivan Franko State University 40 Velyka Berdychivska str., Zhytomyr, Ukraine, 10008
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