Abstract
270,597 newborns were screened from 1979 to 1990 in Okayama Prefecture. Forty-six patients with congenital hypothyroidism (CH) were found, exhibiting a frequency of approximately 1:5900. 77.3% of the patients whose types were determined had ectopic CH. Sex ratio of the total CH found was M F = 1:1.4. DQ or IQ measurement of patients found by screening was significantly higher than that of patients found before the start of screening. All criteria for quality control such as sensitivity, specificity, retest rate, and false positive and negative rates were within acceptable limits. These results suggest that screening has worked efficiently and has been successful in patient intervention. However, to avoid missing any patients, the cutoff point for TSH concentration should be selected carefully.
Published Version
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