Abstract
The increasing prevalence of chikungunya virus (CHIKV) in the United States and around the world, and the lack of antiviral treatments or vaccines highlight the potential threat of a global CHIKV pandemic. CHIKV is a mosquito-borne alphavirus that is currently causing outbreaks in many parts of the world, including the Americas, India, Africa, and parts of Europe. Host response against CHIKV infection is complex and remains unresolved. Here we discuss the role of the host restriction factor—bone marrow stromal antigen 2 (BST-2) also known as tetherin—as an intrinsic factor involved in CHIKV infection. Recent research reports suggest that the release of nascent CHIKV particles and replication of CHIKV in cultured cells and in animal models is impaired by the expression of BST-2. In this chapter, we discuss available published data on how BST-2 restricts CHIKV and how CHIKV in turn neutralizes BST-2.
Published Version
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