Abstract
Abstract The recent progress in nano-sciences has changed the course of cancer treatment with a specialized focus on the targeted delivery of drugs. Polymeric nanogels have especially gained much attention as a possible way to achieve a controlled and targeted drug delivery in chemotherapeutic research for cancer treatment. Nanogels are the nano-sized hydrogel particles that are formed by physically or chemically crosslinked polymer. First nanogel polymer based on gelatin was reported in 1989. Nanogels offer the possibility of active targeting strategies as their surface functionalities can easily be modified and used for the conjugation of targeting moieties. Careful introduction of specific polymeric modalities changes ordinary polymeric nanogels into advanced stimuli-responsive nanogels capable of altering their physicochemical properties in response to various external or internal stimuli. The emphasis of this report is on the fundamental understanding of the responsive behavior of nanogel against various stimuli with applications in cancer therapy.
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