Abstract
A powdered diet containing 100 or 3ppm Fe was fed to rats starting at the age of 3weeks. The voluntary activity level was checked using a wheel in the cage during the 17th week after the beginning of supplementation. Significantly less activity was seen in the 3ppm Fe group during both light and dark periods. After 20weeks, the blood and diencephalon were sampled from both groups. Lower hematocrit and blood hemoglobin content was observed in the 3ppm Fe group. The level of 70kDa heat shock cognate (HSC70) expression was greater in the diencephalon of the 3ppm Fe group. In addition, the distribution of HSC70 was determined by proximity ligation assay. More HSC70-positive as well as total cells were noted in several areas of the diencephalon of the iron-deficient rats. The altered expression and distribution of HSC70 might play some role in the neurological changes.
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