Abstract
We appreciate the comments of Dr. De Boer and colleagues, who ask important questions about the effects of anticoagulant treatment and the characteristics of those patients who experienced thromboembolic events. As we mentioned in the article, it is difficult to accurately assess the effects of warfarin or aspirin in the SCD-HeFT database for several reasons, the most important of which being that such therapy was not randomized.1 …
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