Abstract
We appreciate the careful review by Drs Taylor, Hare, and Mann of our article1 and their thoughtful letter in response to it. The importance of studying the combination of hydralazine and isosorbide dinitrate in heart failure has been highlighted both by our review and by their letter. It is not uncommon for drug research and development to fall into either of the 2 following scenarios. Some drugs may enter phase III trials without a comprehensive understanding of their systemic and organ-specific mechanistic effects. In …
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