Abstract
The theoretical analysis of responses of calcium-dependent membrane-associated signaling systems to weak extremely low-frequency periodic signals with different waveform parameters was performed on a model suggested recently (Gapeyev and Chemeris, Electro- and Magnetobiology 19, 21–42, 2000). Calcium channels of the plasma membrane were chosen as the target for the influence of external periodic signals. The effect of external signals was manifested as an increase in average [Ca2+]i at certain parameters of the signals. The effect had a threshold dependence on the relative amplitude of the external signal. The effect character was shown to depend strongly on a sequence of delivery of the external stimuli. The effect also depended on the phase of the influencing signal with respect to the moment of the chemical stimulation of the cell. Under the influence of sine-wave, rectangular, and sawtooth external signals, amplitude- and phase-frequency “windows” of the rise in average [Ca2+]i were revealed. Location...
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