Abstract
The response of Acidithiobacillus ferrooxidans ATCC 23270 to variations in extracellular pH was investigated based on some gene expression profiling. Real-time PCR analysis revealed that cells elicited both general and specific transcriptional responses when challenged with environmental acid (pH 1.3) or base (pH 2.3) conditions over a 6-h period. These responses included the differential expression of genes functionally linked to cell membrane structure, transcriptional regulation and signal transduction. Response to acid stress included the elevated expression of genes encoding the two component response regulator OmpR, the global regulator Fur, and the RNA polymerase sigma-38 factor (rpoS) and so on. Collectively, these results suggest that Acidithiobacillus ferrooxidans modulates multiple cell envelope components, transcription regulators and as part of its response to changing external pH conditions.
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