Response gene to complement-32 serves as a functional dyad in smooth muscle cells: Cell cycle activator and mediator of cellular differentiation

S.I Vlaicu,A Tatomir,D Boodhoo,M Fosbrink,T.C Badea,V Rus,H Rus

doi:10.1016/j.atherosclerosis.2022.06.199

Response gene to complement-32 serves as a functional dyad in smooth muscle cells: Cell cycle activator and mediator of cellular differentiation

S.I Vlaicu, A Tatomir + Show 5 more

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https://doi.org/10.1016/j.atherosclerosis.2022.06.199

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Journal: Atherosclerosis

Publication Date: Aug 1, 2022

Affiliation: Iuliu Hațieganu University of Medicine and Pharmacy, Transylvania University of Brașov

#Response Gene To Complement-32 #Cell Cycle Activation + Show 8 more

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Abstract

Background and Aims : Proliferation of endothelial cells (EC) and smooth muscle cells (SMC) and SMC phenotypic plasticity are critical processes in the development of atherosclerosis. We have previously shown that the sublytic C5b-9 effector Response Gene to Complement-32 (RGC-32) regulates EC proliferation, migration, and cytoskeletal reorganization. Our goal was to explore the effect of RGC-32 on cell cycle activation and TGF-β induced differentiation of SMC and the extracellular matrix (ECM) production.

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