Abstract
Response: Commentary: Elimination of Left-Right Reciprocal Coupling in the Adult Lamprey Spinal Cord Abolishes the Generation of Locomotor Activity.
Highlights
In the CNS, central pattern generators (CPGs) produce the basic temporal pattern of electrical motor activity that produces rhythmic behaviors such as locomotion
Regarding the previous commentary (Cangiano and Grillner, 2018), there are at least two relevant questions concerning the locomotor rhythm generating capabilities of CPG modules in right and left hemispinal cords in adult lampreys: (a) Does the burst activity generated by hemi-spinal cords represent well-coordinated locomotor activity? (b) Does generation of burst activity by hemi-spinal cords represent a normal physiological capability of these spinal circuits, or is this capability manifested under certain, possibly artificial, experiment conditions? In the text below, all page numbers and figures refer to those in our previous study (Messina et al, 2017)
A longitudinal midline (ML) lesion was performed along the rostral spinal cord of adult lampreys, and rostral muscle activity and caudal muscle activity were recorded in response to sensory stimulation of the anterior head (Figure 3A)
Summary
In the CNS, central pattern generators (CPGs) produce the basic temporal pattern of electrical motor activity that produces rhythmic behaviors such as locomotion. Regarding the previous commentary (Cangiano and Grillner, 2018), there are at least two relevant questions concerning the locomotor rhythm generating capabilities of CPG modules in right and left hemispinal cords in adult lampreys: (a) Does the burst activity generated by hemi-spinal cords represent well-coordinated locomotor activity?
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