Abstract
Objective: to evaluate the significance of respiratory syncytial viral infection in lower respiratory tract infections in hospitalized children 1 year of life and its features. Materials and methods: the research was carried out from march 2015 till october 2016. We enrolled all children under 1 year with acute lower respiratory tract infections. A real-time PCR method was used to detect viruses in nasopharyngeal swabs. The levels of CRP and procalcitonin were estimated. Results: We enrolled in our research 356 children with acute lower respiratory tract infections. RS-virus was detected in 129 patients (36,2%). Single viral infection was detected in 79.9% of cases. The median age of the patients was 4 (1; 7) months. 14,7% of children with RS-infection had burdened premorbid background, 16.7% of children were premature. Severe forms of RS-infection have been detected in 26.4% children. These were the children of the first months of life, the median age was 2 (1; 4) months. RS-infection proceeded mostly in the form of bronchiolitis (62%). WBC count in pneumonia and bronchiolitis associated with RSV significantly differed (10,6 against 9,2×109 /l, p 0,028). The level of CRB was 1,8 (0,5; 6,8) mg/l, procalcitonin 0,075 (0,059; 0,104) ng/ml, there was no difference in bronchiolitis and pneumonia. Conclusions: Respiratory syncytial virus infection is the leading cause of lower respiratory tract infections in hospitalized children 1 year of life. There was no increase of CRP and procalcitonin. The risk factor of severe RS- infection is early age (less than 6 months).
Highlights
Objective: to evaluate the significance of respiratory syncytial viral infection in lower respiratory tract infections in hospitalized children 1 year of life and its features
Rodriguez-Martinez, Ivonne Emilce Quilaguy et al Predictors of severity and mortality in children hospitalized with respiratory syncytial virus infection in a tropical region
Caroline Breese Hall, Geoffrey A.Weinberg, Aaron K
Summary
Резюме Цель: оценить значимость респираторно-синцитиальной вирусной инфекции в структуре респираторных вирусных инфекций, протекающих с поражением нижних дыхательных путей у госпитализированных пациентов первого года жизни, и особенности ее течения. 29 дней, госпитализированные в стационар с инфекциями нижних дыхательных путей. Результаты: в исследование было включено 356 детей с инфекциями нижних дыхательных путей, нуклеиновые кислоты РС-вируса выявлены у 129 пациентов (36,2%). Медиана возраста пациентов составила 4 (1; 7) месяца. Это были дети первых месяцев жизни, медиана возраста составила 2 (1; 4) месяца. Уровень С-реактивного белка в среднем составлял 1,8 (0,5; 6,8) мг/л, прокальцитонина 0,075 (0,059; 0,104) нг/мл, не было различий при бронхиолитах и пневмониях. Выводы: респираторно-синцитиальная вирусная инфекция – ведущая причина поражения нижних дыхательных путей у госпитализированных пациентов первого года жизни. Ключевые слова: РС-вирус, инфекции нижних дыхательных путей, дети, пневмония, бронхиолит, СРБ, прокальцитонин
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