Abstract
Oxygen consumption of sarcoma cells from the soft-shell clam Mya arenaria L. was studied. Hemolymph of clams in the terminal stage of sarcoma was strongly hypoxic. In early cases of sarcoma, partial pressure of oxygen in the hemolymph did not differ from the control animals but declined as the sarcoma advanced, and finally fell below the detection limit causing death of sarcomatous clams. Mitotic index declined as the sarcoma progressed and was 100 × lower in hypoxic plasma in the terminal stage than in early cases. Oxygen consumption of the sarcoma cells in 15% salinity seawater (18 °C) was 3.9 × 10 −4 μl· h −1·cell −. Respiration rates declined in salinities < 7.5‰ and > 15% . Temperature stress (37 °C) depressed oxygen consumption before mortality could be detected but returning the cells to 18 °C increased oxygen consumption above the initial level.
Published Version
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