Abstract
ABSTRACT In HCl–NaAc buffer medium of pH 3.25 ∼ 3.85, when tolterodine tartrate (TDT) reacted with alizarin green (AG) by electrostatic force and hydrophobic force to form an ion-association complex, the resonance Rayleigh scattering (RRS) intensity could be enhanced greatly, and a new RRS spectrum appeared. The maximum RRS peak was at 344 nm, and the other RRS peak was located at 454 nm. Under optimum conditions, there is a linear relationship between the RRS intensity and TDT concentration in the range of 7.06 × 10−7 to about 3.12 × 10−5 mol/L. The method is very sensitive, and the detection limit (3σ/K) for tolterodine tartrate is 3.31 × 10−7 mol/L. The optimum reaction conditions and influence factors were investigated. A highly sensitive, simple, and fast method is proposed for the determination of TDT.
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