Abstract
A subcritical carbon dioxide mobile phase used in conjunction with polar modifiers was found to be effective for the resolution of racemic amides and phosphine oxides on a β-cyclodextrin-bonded phase. This seems to be the first example of a chiral separation in the normal phase mode for this type of stationary phase. The method has been extended to normal phase liquid chromatography. A chiral recognition model is proposed. It was found that the effects of polar modifiers on stereoselectivity were different from those in reversed-phase chromatography.
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