Abstract
This chapter discusses the resolution of cysteine and methionine enantiomers. Studies of the metabolism of cysteine and methionine generally address either implicitly or explicitly the enantiomeric specificity of the reactions involved. Studies of the substrate specificity of enzymes as well as the evaluation of the enantiomeric purity of reagent amino acids (particularly isotopically labeled amino acids) require analytical methods for the resolution of methionine and cysteine enantiomers. Recently, developed methods for the separation of amino acid enantiomers by HPLC in the presence of chiral mobile or stationary phases provide convenient procedures for such analytical resolutions. Preparative resolution of isotopically labeled sulfur amino acids remains of considerable interest because only racemates of the materials of interest are available in any cases. The procedures described illustrate the analytical and preparative resolution of some of the sulfur amino acids.
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