Resistance training attenuates fat mass regain after weight loss in ovariectomized rats

Abstract

Objective The aim of the present study was to investigate the effects of maintaining only one of the two components of a food restriction (FR) + resistance training (RT) regimen on the regain of body weight and fat mass (liver and adipocytes) in ovariectomized (Ovx) rats. Methods Five week Ovx rats were submitted to a weight loss program consisting of a 26% FR combined with RT (OvxFR + RT) for 8 weeks. RT consisted of climbing a 1.5 m vertical grid with a load attached to the tail, 20–40 times with progressively increasing loads 4 times/week. Following this weight loss intervention, OvxFR + RT rats were sub-divided into 3 groups for an additional 5 weeks: 2 groups went back to a normal ad libitum feeding with or without RT and the other group kept only FR. Results Combined FR + RT program in Ovx rats led to lower body mass gain, liver triacylglycerol (TAG) levels, and fat mass gain compared to sedentary normally fed Ovx rats ( P < 0.01). Stopping both FR and RT over a 5 week period resulted in the regain of body weight, intra-abdominal fat pad weight and liver TAG ( P < 0.01). When only FR was maintained, the regain of body and fat pad weight as well as liver and plasma TAG concentrations was completely prevented. However, when only RT was maintained, regain in the aforementioned parameters was attenuated but not prevented ( P < 0.05). Conclusion It is concluded that following a FR + RT weight loss program, continuation of only RT constitutes an asset to attenuate body weight and fat mass regain in Ovx rats; although the impact is less than the maintaining FR alone. These results suggest that, in post-menopausal women, RT is a positive strategy to reduce body weight and fat mass relapse.