Abstract
Ingesting androstenediol or androstenedione does not increase serum testosterone concentrations in men, but does elevate serum estradiol concentrations. The elevation in serum estradiol may be exaggerated by resistance exercise. Sublingual administration of androstenediol acutely increases serum testosterone concentrations. However, the effect of resistance exercise on the hormonal response, and the duration of change in serum hormones due to sublingual androstenediol are unknown. PURPOSE This project evaluated the effects of a single session of resistance exercise on the hormonal response to sublingual androstenediol. METHODS Six resistance trained males (22.8 ± 1.0 y, 182.0 ± 3.9 cm, 92.1 ± 2.1 kg, 19.2 ± 3.2% body fat) were administered either sublingual placebo (PL) or 21.4 mg androstenediol (AN) under conditions of a single session of full body resistance exercise consisting of 2 sets of 8–12 repetitions at ∼85% 1-RM (EX) or no exercise (REST). Blood samples were collected before supplementation, at 1, 2, 3, 4, 8, and 12 h post supplementation, with the exercise occurring between h 1 and 2.FigureRESULTS There were no differences in the mass lifted or number of sets or repetitions completed between AN and PL. DISCUSSION These findings indicate that sublingual androstenediol acutely elevates serum testosterone and estradiol concentrations, and that resistance exercise does not alter the increase in serum estradiol or testosterone. These data also indicate that the change in serum hormones due to sublingual androstenediol last less than 8 hours. This project was supported by a Faculty Development Grant from Georgia Southern University.
Published Version
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