Abstract

Researchers in the Departments of Medicine and Neurology at Northwestern University Feinberg School of Medicine, Chicago, IL evaluated the effect of simulation-based mastery learning (SBML) on internal medicine residents’ lumbar puncture (LP) skills, assessed neurology residents’ acquired LP skills from traditional clinical education, and compared the results of SBML to traditional clinical education.

Highlights

  • Long interval intracortical inhibition was significantly reduced and the cortical silent period was significantly shortened in patients with succinic semialdehyde dehydrogenase (SSADH) deficiency compared to heterozygous parents and controls

  • PGY1 internal medicine residents (n=58) improved from a mean of 46.3% to 95.7% after simulationbased mastery learning (SBML) (p

  • Simulator training and adherence to a procedural checklist are important in the preparation and performance of an lumbar puncture (LP) by residents

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Summary

Introduction

GABA-ERGIC DYSFUNCTION IN SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY Investigators at the Clinical Epilepsy and Neurorehabilitation Sections, NIH, Bethesda, MD; Albert Ludwigs University, Freiberg, Germany; and Children’s National Medical Center, Washington, DC used transcranial magnetic stimulation (TMS) to quantify the excitation and inhibition in primary motor cortex in 8 patients (mean age 15.4 years) with succinic semialdehyde dehydrogenase (SSADH) deficiency. Long interval intracortical inhibition was significantly reduced and the cortical silent period was significantly shortened in patients with SSADH deficiency compared to heterozygous parents and controls.

Results
Conclusion
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