Abstract
We used high-resolution Kelvin probe force microscopy (KPFM) to investigate the immobilization of a prostate specific antigen (PSA) antibody by measuring the surface potential (SP) on a MoS2 surface over an extensive concentration range (1 pg/ml–100 μg/ml). After PSA antibody immobilization, we demonstrated that the SP on the MoS2 surface characterized by KPFM strongly correlated to the electrical signal of a MoS2 bioFET. This demonstration can not only be used to optimize the immobilization conditions for captured molecules, but can also be applied as a diagnostic tool to complement the electrical detection of a MoS2 FET biosensor.
Highlights
Research Update: Nanoscale surface potential analysis of MoS2 field-effect transistors for biomolecular detection using Kelvin probe force microscopy
After prostate specific antigen (PSA) antibody immobilization, we demonstrated that the surface potential (SP) on the MoS2 surface characterized by Kelvin probe force microscopy (KPFM) strongly correlated to the electrical signal of a MoS2 bioFET
Lee et al reported that MoS2 fieldeffect transistor (FET) offer a highly hydrophobic MoS2 surface without any other post-processing and they show a high affinity to prostate specific antigen (PSA) antibody.[17]
Summary
Research Update: Nanoscale surface potential analysis of MoS2 field-effect transistors for biomolecular detection using Kelvin probe force microscopy. We have used KPFM to explore the variation of SP generated by adsorbed PSA antibodies on a 2D MoS2 bioFET biosensor.
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