Research trends and hotspot topics of exosomes based on citespace bibliometric analysis

Abstract

Exosomes are membrane vesicles that exist in pathological or normal cells and are considered to be specifically secreted, contain complex RNAs and proteins, participate in intercellular communication functions, and have functions in organismal immune response, antigen presentation, cell migration, cell differentiation, and tumor invasion. In recent years, with the explosion of the development of minimally invasive diagnostics, the research of exosomes has been rapidly developed, and the number of articles published in this field has increased dramatically, and many articles summarize the published papers in a review-type analysis. In this paper, we use bibliometric analysis combined with theoretical analysis and pathfinding network scaling to visualize data and objectively count the development process, current research, and development trend of the corresponding field by analyzing the literature of the specified field. This paper presents the data visualization by analyzing the literature of the specified field to objectively count the development process, current research and development trend of the corresponding field. This paper presents a retrospective analysis and review of the articles on exosomes in the last 20 years (2001–2021) based on the bibliometric analysis method of CiteSpace software, while presenting the problems of current research and discussing the challenges encountered in the future, hoping to provide new ideas for the development of research in this field.