Abstract
ObjectiveA lot of research has focused on the field of chemotherapy-induced peripheral neuropathy (CIPN). In this study, we performed a bibliometric analysis of CIPN-related publications to identify the key research areas and trends over the last 20 years.MethodsWe searched the Web of Science core collection for publications related to CIPN that were published between January 2001 and September 2021. We then performed bibliometric analysis and visualization using Microsoft Excel 2019, VOSviewer, and the Bibliometric online analysis platform (https://bibliometric.com/).ResultsIn total, we identified 2,188 eligible publications in the field of CIPN, with an increasing trend in the annual number of publications. The United States and Italy were dominant in the CIPN field. Supportive Care in Cancer was the most productive journal. G. Cavaletti and A.A. Argyriou published the largest number of papers. Of all institutions, the University of Milano-Bicocca, Italy, published the highest number of papers. Analysis of the co-occurrence of keywords revealed the specific characteristics relating to the four main clusters: oxaliplatin, paclitaxel, pain management, and quality of life (QOL). Newly emerging research focusses predominantly on neuroinflammatory mechanisms and non-pharmacological interventions for CIPN.ConclusionThis bibliometric study reviewed the evolutionary trends in CIPN research and identified current research hotspots and research trends. In addition, we identified journals, institutions, and authors, with the highest levels of impact to enhance the collaboration and learning.
Highlights
Chemotherapy-induced peripheral neuropathy (CIPN) has become a rising health concern due to the increasing number of cancer survivors and prolonged survival rates
We identified the 15 most influential authors in the CIPN field based on the Hirsch index (H-index) and the number of publications (Table 2)
Our analysis showed that the United States plays an essential role in CIPN research, followed by Italy, Japan, and China; about 56.4% of all publications were published by researchers in the United States
Summary
Chemotherapy-induced peripheral neuropathy (CIPN) has become a rising health concern due to the increasing number of cancer survivors and prolonged survival rates. 30% of patients still report varying degrees of CIPN 6 months after chemotherapy; this condition has a notable effect on the lives in cancer survivors [3, 4]. There is no effective strategy for preventing CIPN and no recognized therapeutic agent at the present time. Over the past two decades, thousands of published manuscripts have reported mechanistic, diagnostic, therapeutic, and preventive studies of CIPN, making it very difficult for researchers to identify highly influential articles and research hotpots. Manual literature searches can no longer accurately identify potential trends in the development of CIPN. There is an urgent need to develop new literature retrieval strategies for the fast data collation and mining
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