Abstract
Posttraumatic stress disorder (PTSD) is to a persistently severe mental disorder which is caused by individual exposure to some unusual threatening or catastrophic stressful events. Its essential clinical manifestations refer to repeated playback of traumatic experience, durative avoidance of related clues, mental numbness or affection paralysis, and persistent increase of vigilance level. At present, the pathogenesis of PTSD has not been fully elucidated, and the clinical therapeutic effect has not been ideal. Generally, the classical animal model of PTSD is mouse; the domestic and international researches in the animal model of PTSD in recent years remain active, which are summarized as follows.
Highlights
Posttraumatic stress disorder (PTSD) is to a persistently severe mental disorder which is caused by individual exposure to some unusual threatening or catastrophic stressful events
According to the most widely used DSM-IV PTSD diagnostic criteria, the 17 clinical symptoms involved in the clinical symptom criteria of PTSD are divided into three clinical symptom clusters, including: The first group is hyperarousal: manifested as persistent anxiety, irritability, insomnia, and decreased concentration; the second group surrounds the intrusions experience: patients have difficulty recalling stressful events autonomously, there are a lot of intrusive experiences of traumatic images, flashbacks and recurring painful dreams; the third set of symptoms is avoidance: patients avoid things related to traumatic events, alienation from people, no emotional experience
A large number of studies have shown that PTSD may involve different psychopathological and biological processes in different symptom clusters [23], and play different roles in the development and treatment of PTSD [24]
Summary
According to foreign data, for men, the incidence of high incidence of PTSD in human trauma is rape (65%), war (38.8%), sudden death of the lover (12.6%), harassment (12.2%); for women, rape (45.9%), harassment (26.5%), physical assault (21.3%), and sudden death of the lover (16.2%). Many studies have shown that the age of adult cancer patients is inversely proportional to the symptoms of PTSD [9] [10] [11]. PTSD is a common serious psychological disorder among different disaster survivors in China, there are very few studies and practices on this disease, which seriously restricts the development of mental health plans and psychological assistance work. The most typical symptoms are flashback, nightmares, and intrusive appearance, sometimes combined to be called re-experience symptoms These typical symptoms are considered to be direct or indirect effects of abnormal memory processing in patients with PTSD [19], so PTSD is considered to be a pathological memory-causing and persistent disease [20] [21]. It has been shown that the impact factors of many journals closely related to disease research are increasing year by year, which fully demonstrates that basic research around diseases has become a major part of biomedical research
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