Research Progress on Fluoride Solution Promoting the Survival of Replanted Teeth

Abstract

Tooth replantation is an operation in which the lost teeth due to various reasons are treated and replanted in the alveolar socket. The key lies in the regeneration of the alveolar blood vessels and the regeneration of the alveolar bone. Fluoride has been proved to be a substance that promotes the growth of bone cells and has been widely used worldwide. Fluorine is a rare element that mixes with bone minerals during the osteogenic phase. It is a known non hormonal factor that can affect bone formation and has a bidirectional regulatory effect on bone formation. Long term low doses can promote bone formation, while high doses can cause osteoporosis or osteosclerosis. Osteocalcin can regulate bone metabolism, maintain normal bone calcification, inhibit cartilage calcification and irregular crystal precipitation. The mechanism of action of fluoride is that fluoride can stimulate osteoblasts to secrete osteocalcin, allowing more hydroxyapatite crystals to combine with it and precipitate in the bone matrix. Therefore, an appropriate concentration of fluoride solution can promote bone remodeling of alveolar bone and dentin. Through the effect of fluorine on bone cells, fluoride can be applied to tooth replantation surgery in order to improve the success rate of surgery. It was found that fluoride can regulate bone formation by stimulating the proliferation and differentiation of immature osteoblasts, ultimately affecting tooth replantation.