Abstract
SCN9A,encoding the voltage-gated sodium channel alpha subunit type Ⅸ,is predominanfly expressed in sensory and sympathetic neurons,with strikingly high levels in DRG.In 2004,Yang-yong and others firstly found out that the mutations in SCN9A caused primary erythermalgia(IEM),and then researchers found out that SCN9A mutations also caused paroxysmal extreme pain disorder(PEPD)and congenital indifference to pain(CIP).The pathogenic mechanism of SCN9A mutations and the relationship between SCN9A and pain have gradually become a hot spot of today's research.Up till now.there are many studies on SCN9A gene either on molecular level based on patch clamp technique or on global level based on gene knock-out technique.In this article we make a review of these studies. Key words: SCNgA; Primary erythermalgia; Paroxysmal extreme pain disorder; Congenital in difference to pain
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
