Abstract
SCN9A,encoding the voltage-gated sodium channel alpha subunit type Ⅸ,is predominanfly expressed in sensory and sympathetic neurons,with strikingly high levels in DRG.In 2004,Yang-yong and others firstly found out that the mutations in SCN9A caused primary erythermalgia(IEM),and then researchers found out that SCN9A mutations also caused paroxysmal extreme pain disorder(PEPD)and congenital indifference to pain(CIP).The pathogenic mechanism of SCN9A mutations and the relationship between SCN9A and pain have gradually become a hot spot of today's research.Up till now.there are many studies on SCN9A gene either on molecular level based on patch clamp technique or on global level based on gene knock-out technique.In this article we make a review of these studies. Key words: SCNgA; Primary erythermalgia; Paroxysmal extreme pain disorder; Congenital in difference to pain
Published Version
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