Abstract
As a functionally unique subset of T cells, regulatory T cells (Treg) suppress tumor immune responses effectively through a variety of mechanisms and play an important role in tumorigenesis and tumor progression. With the deepening research of Treg, There is growing evidence suggests that Treg participate in the formation and development of hepatic tumor, especially hepatocellular carcinoma(HCC). Decreasing the number of Treg could strengthen the antitumor immunity. There fore, the number of Treg is an independent risk factor for HCC prognosis. On the contrary, some cytokines in hepatic tumor microenvironment can affect the phenotype of Treg and enhance their suppressive function. Key words: Regulatory T cell; Hepatocellular Carcinoma; immunosuppression; immunotherapy
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