Abstract
Objective To detect the infiltration of regulatory T cells(Tregs)in gastric cancer and evaluate its correlation with prognostic significance of gastric cancer. Methods The distribution of tumor-infiltrating Tregs and the expression of forkhead box protein 3(Foxp3)-positive cancer cells were detected by immunohistochemistry staining technique to evaluate the prognostic effects in 106 cases of gastric adenocarcinoma. Results The average number of intratumoral Tregs(7.36± 8.06) was significantly greater than that in paired normal mucosa tissues(2.10±2.97, P 0.05).The number of Tregs in cancer nest was positively correlated with OS(P< 0.01). Conclusion There are differences in the distribution of infiltrated Tregs between cancer nest and cancer stroma in gastric cancer. The level of the Tregs infiltration in cancer nests can be regarded as a predictive indicator for the prognosis in gastric cancer. Key words: Gastric carcinoma; Regulatory T cells
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
