Research progress of re-epithelialization in decellularized trachea matrix

Abstract

Long-segment tracheal defects are difficult to be managed by conventional surgical means, which often requires tracheal transplantation.Studies have confirmed that the capacity of tissue engineering techniques in restoration of extensive tracheal defects in animals and human.Decellularized tracheal matrix has attracted widespread attention for its advantages, such as excellent biocompatibility.Re-epithelialization of the tissue engineered trachea, which remains the major obstacle in tracheal transplantation, plays an important role in protecting the grafts from infection and restenosis.To date, some research focuses on the re-epithelialization of the tissue engineered trachea, but achievements are still far from desired, and further studies are needed to ensure the visibility of the application of tissue engineered trachea. Key words: Tracheal transplantation; Tissue engineering; Decellularized trachea matrix; Re-epithelialization