Abstract
Mitogen-activated protein kinase (MAPK) signaling pathways may be involved in various activities of cells such as apoptosis, differentiation and autophagy. In human cells, MAPK signaling pathways mainly contain Erk, p38 MAPK and JNK, and each of them is highly specific and has its own function. MAPK signaling pathways are closely related to the development of leukemia. The effect of MAPK signaling pathways on leukemia cells is mainly mediated by affecting cell apoptosis, cell drug resistant , cell autophagy and differentiation. In this review, recent advances on the study of MAPK in leukemia are reviewed. Key words: JNK pathway; p38 pathway; Erk pathway; Leukemia
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