Research progress of diagnosis and treatment on group B Streptococcus infection in perinatal period

Abstract

Group B Streptococcus (GBS) is one of the important pathogens in adverse effects on pregnancy outcomes. GBS is also the leading cause of complications such as neonatal sepsis and meningitis and death of perinatal infants. There are ten different serotypes of GBS infection. GBS screening for pregnant women in perinatal period can provide references for clinicians taking intrapartum antibacterial prophylaxis (IAP) measures timely on pregnant women to prevent perinatal GBS infection, and effectively reduce infection rate of perinatal GBS. As a simple and safe method to prevent GBS infection, GBS vaccines have been paid more and more attention. GBS vaccines are currently the most prospective measure to prevent neonatal GBS infection through maternal immunity, but they have no preventive effects on neonatal-late onset GBS infection. This article focuses on adverse pregnancy outcomes, risk factors, effects of regional differences, diagnosis, treatment caused by perinatal GBS infection and current research development of GBS vaccines. Key words: Streptococcus agalactiae; Infectious disease transmission, vertical; Sepsis, neonatal; Income, socioeconomic factors, family characteristics; Pregnancy outcome; Vaccination, maternal