Abstract
The matrix metalloproteinases (MMPs) can degrade dentin collagen fibers, which plays an important role in affecting the bonding durability of dental restoration. Therefore, inhibiting the activity of dentin MMPs is the key to improve bonding durability. As inhibitors of MMPs, cross-linking agents can not only inhibit the activity of MMPs, but also promote the crosslinking of dentin collagen fibers. These two functions enable cross-linkers to improve dentin bonding. In this article, the research progress of common cross-linking agents in inhibiting MMPs and improving bonding durability of dentin was reviewed. Key words: Matrix metalloproteinases; Enzyme inhibitors; Cross-linking reagents; Dentin bonding agents; Dental bonding; Bonding durability
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