Research Progress of Apoptosis Inhibitory Protein Survivin in Gastric Cancer

Abstract

Survivin is an important member of the apoptosis inhibitory protein family, which plays an important role in suppressing apoptosis, promoting proliferation and vascular formation. The occurrence and development of tumors are related to apoptosis and imbalance of proliferation. Gastric cancer is the most common malignant tumor in the digestive system. Due to the inadequate symptoms of early symptoms, most of them have entered the middle and late stages during diagnosis. It is easy to relapse and metastasize. The mortality rate is high, which seriously endangers human health. Research have found that Survivin expresses high in gastric cancer tissue, participating in the proliferation of tumor cells, inhibiting apoptosis and the formation of blood vessels, and is of great significance to the diagnosis, judgment transfer and prognosis evaluation of gastric cancer, especially the value of combined with a number of indicators is greater. Therefore, finding an early diagnosis and judging the ideal tumor logo combination of the early diagnosis and judgment of the prognosis is important. This article reviews the biological characteristics of Survivin and its research progress in gastric cancer, so as to provide theoretical basis for the diagnosis of gastric cancer and new ideas for the successful prevention and treatment of tumors.