Research progress in the multiple signaling transduction pathways of vitamin E succinate inducing apoptosis in breast cancer cells

Abstract

Vitamin E succinate (VES) has been recently recognized as a neotype tumor suppressor.However, the molecular mechanisms that VES induces apoptosis in breast cancer cells have not been validated. Current studies have indicated that VES induces breast cancer cell apoptosis through TGF-β signaling transduction pathways, Fas signaling transduction pathways, and JNK signaling transduction pathways.Other signaling transduction pathways still need to be investigated further. Key words: Breast neoplasms; Signal transduction; Apoptosis