Abstract
Hepatitis C virus (HCV) is an RNA virus with high genetic variability, and the convalescent humans and chimpanzees can be re-infected after re-exposure to heterologous virus.Thus, developing a vaccine against HCV is a difficult challenge.Studies of a prophylactic vaccine in chimpanzees have elucidated that induction and maintenance of helper and cytotoxic T lymphocytes against multiple viral epitopes are necessary for viral clearance and protection against chronic infection.Multispecific B-cell responses can rapidly induce cross-neutralizing antibodies, which conduce to cellular immune responses.This review summarizes recent progress in molecular virology and antiviral immune response for HCV vaccine candidates, and discusses investigations of vaccine candidates in the chimpanzees and patients infected with HCV. Key words: Hepacivirus; Antibodies; Vaccines; Models,animal
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call