Abstract
As one of the fast developing technologies in the 21st century,nanotechnology has been applied in many fields including biomedicine.Nanomaterials provide bright avenue in disease diagnosis and treatment.Most significantly,metallic and metallic oxides nanoparticles have been widely used in biomedicine.Noble-metal nanoparticles,such as gold and silver,can act under laser irradiation as effective photothermal transducers for triggering localized hyperthermia of tumors.However,most of nanomaterials show toxicity in vivo.To use the most effective metallic nanoparticle in various biomedical applications,particle characteristics including size,surface chemistry,special properties and toxicity have to be fully investigated.In this review,the progress in the development of metallic nanoparticle based therapies for various biomedical applications as well as remaining challenges for such clinical use are discussed.
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