Abstract
Background: Vestibular migraine (VM) is the most common cause of spontaneous vertigo with no specific physical and laboratory examinations, and is an under-recognized entity with substantial burden for the individual and the society. In this study, by observing the brainstem auditory evoked potential (BAEP) and cognitive function of VM patients, the possible laboratory diagnostic indicators of VM and the influence of disease on cognitive function were discussed.Method: The study included 78 VM patients, 76 migraine patients, and 79 healthy individuals. The age, gender, and other clinical history of the three groups matched. All participants underwent BAEP examinations, in which patients in the migraine group and outpatients of the VM group were in the interictal period, and inpatients in the VM group were examined during episodes, while all patients tested for the Addenbrooke's cognitive examination–revised (ACE-R) scale were in the interictal period. The differences in BAEP and ACE-R scores between the three groups of members and their relationship with the clinical features of VM patients were analyzed.Result: The peak latency of I, III, and V wave in the BAEP of the VM group was longer than that of the migraine group and the control group (p < 0.05). The peak latency of V wave in the BAEP of the migraine group was longer than that of the control group (p < 0.05). The ACE-R of the VM group scored lower than the migraine group in terms of language fluency and language (p < 0.05), and lower than the control group in terms of total score, language fluency, language, and visuospatial (p < 0.05); and the ACE-R of the migraine group scored lower than the control group in the total score and visuospatial (p < 0.05).Conclusion: Migraine patients have brainstem dysfunction, and VM patients have more severe brainstem dysfunction than migraine patients, suggesting that VM patients have both central nervous system damage and peripheral nerve damage. Migraine patients have cognitive impairment, while cognitive impairment in VM patients is more severe than in migraine patients.
Highlights
Vestibular migraine (VM) is a clinically common disease with recurrent dizziness/vertigo with nausea and vomiting with or without headache [1]
Brainstem auditory evoked potential (BAEP) is a potential activity change caused by sound stimulation in the brainstem auditory conduction pathway
The purpose of this study is to investigate the changes of brainstem auditory evoked potential (BAEP) and cognitive function in VM patients, to determine whether the auditory pathway and the brainstem functional state of VM patients have been changed, and to further study whether the pathogenesis of VM is related to brainstem and peripheral nerves
Summary
Vestibular migraine (VM) is a clinically common disease with recurrent dizziness/vertigo with nausea and vomiting with or without headache [1]. Brainstem auditory evoked potential (BAEP) is a potential activity change caused by sound stimulation in the brainstem auditory conduction pathway. It is an important neurophysiological indicator reflecting the neurological dysfunction from the cochlea to the brainstem, and one of the important means to detect brainstem and peripheral nerve function and evaluate audiology [4,5,6]. By observing the brainstem auditory evoked potential (BAEP) and cognitive function of VM patients, the possible laboratory diagnostic indicators of VM and the influence of disease on cognitive function were discussed
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call