Abstract
Objective To investigate the prevalence of Helicobacter pylori (HP) infection in patients with Parkinson's disease (PD), and analyze the relationship of HP infection with the symptoms, disease progression and motor complications of PD. Methods 72 PD outpatients were randomly selected, and 100 gender and age-matched subjects who took health physical examination were considered as healthy controls. Basic data were collected and estimated by Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn and Yahr stage, the 39-item Parkinson's Disease Questionnaire (PDQ-39), Activity of Daily Living Scale (ADL), Minimum Mental State Examination (MMSE), Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA). All subjects underwent 13C-urea breath test to determine Helicobacter pylori infection status. Results There was no significant difference in HP infection rate between PD and control groups〔37.5% (27 cases) vs. 32.0% (32 cases), P=0.45〕. According to the initial symptoms, PD patients were divided into two groups: bradykinesia/ rigidity group and tremor group. The HP infection rate was higher in bradykinesia/ rigidity group than in tremor group〔52.2% (12 cases) vs. 30.6% (15 cases)〕, but had no significant difference (P=0.08). The mean HY stage was higher in the HP-infected patient group than in the non-infected group〔(2.6±0.7) vs. (2.2±0.9), P=0.03〕. The HP infection rate was higher in patients with HY stage ≥2 than with HY stage <2〔46.4% (26 cases) vs. 6.3% (1 case), P=0.003〕. There were no correlations of HP infection with gender, age, age of onset, UPDRS, UPDRS-Ⅲ, PDQ-39, the course of the disease, wearing-off phenomenon, and dyskinesias. Conclusions The PD patients with HP infection are mainly at middle- and late-stage. HP infection may be related with the progress of the disease. It needs further study and validation by expanding the sample to investigate whether HP infection affects the motor complications. Key words: Parkinson's disease; Helicobacter pylori; Dyskinesias
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