Research on the relationship between microalbuminuria and plasma soluble thrombomodulin in elderly patients with asymptomatic coronary heart disease

Abstract

Objective To investigate the relationship between microalbuminuria and plasma soluble thrombomodulin in elderly patients with asymptomatic coronary heart disease. Methods 106 elderly patients with asymptomatic coronary heart disease were divided into non-microalbuminuria group and microalbuminuria group, and another 50 patients without coronary heart disease were set as control group.The levels of plasma soluble thrombomodulin and microalbuminuria were determined, the differences between two groups and the correlation between plasma soluble thrombomodulin and microalbuminuria were assessed. Results The level of plasma soluble thrombomodulin was(3.36±1.27)μg/L in the control group, (13.96±1.33)μg/L in non-microalbuminuria group, and(17.36±7.48)μg/L in microalbuminuria group, with obvious difference among groups.There were positive correlations of microalbuminuria with plasma soluble thrombomodulin, course of CHD, history of diabetes, hypertension, and serum creatinine levels in elderly patients with coronary heart disease(all P 0.05). The multiple linear regression analysis showed that after adjusting for gender, blood lipid and UA, plasma soluble thrombomodulin, history of diabetes, hypertension and age were independent risk factors for microalbuminuria in elderly patients with coronary heart disease. Conclusions Microalbuminuria and plasma soluble thrombomodulin can appear in asymptomatic stage in elderly patients with coronary heart disease, and there is a positive correlation between microalbuminuria and plasma soluble thrombomodulin, which suggests that early monitoring of microalbuminuria and plasma soluble thrombomodulin could probably contribute to the delayed coronary heart disease progression. Key words: Thrombomodulin; Albuminuria; Coronary disease