Research on the modern clinical herbal administration rules in TCM treatment of ovarian cysts based on data mining

Abstract

ObjectiveTo explore the recent 20 years' herbal administration rules in TCM treatments of ovarian cysts (OCs) based on data mining. MethodsA prescription database for ovarian cysts was established by ACCESS 2007. Importing the database into SPSS17.0 and SPSS Modeler14.1. SPSS17.0 was used for descriptive and cluster analyses, while SPSS Modeler14.1 was used for association rules analysis. ResultsAfter screening, 363 prescriptions were obtained. The 10 most frequently-used Chinese herbal medicines are Zedoaria (Rhizoma Curcumae), Poria cocos (Poria), Common buried rubber (Rhizoma Sparganii), Red peony root (Radix Paeoniae Rubra), Peach seed (Semen Persicae), Danggui (Radix Angelicae Sinensis), Chinese angelica (Ramulus Cinnamomi), Liquorice root (Radix Glycyrrhizae), Pangolin scales (Squama Manis) and Moutan cortex (Cortex Moutan Radicis); the 5 most common syndromes of OCs are qi stagnation and blood stasis, phlegm and blood stasis, uterine blood stasis, stagnation of liver qi and retention of phlegm and dampness, nearly to 54.26%; In association rules analysis, 5 sets of two-herbs association rules were obtained, 17 sets of three-herbs association rules were obtained, 22 sets of four-herbs association rules were obtained and 4 sets of five-herbs association rules were obtained; By clustering, 13 sets of core couplet medicinals were obtained. ConclusionMedicinal herbs for promoting blood circulation to remove blood stasis, resolve hard lumps, for strengthening the spleen, eliminating phlegm, and relieving liver qi stagnation were highly used in the treatment of OCs; Herbs attributed to the Liver Meridian, the Spleen Meridian and the Heart Meridian were highly used in OCs; The compatibility of herbs for promoting blood circulation to remove blood stasis and resolve hard lumps were highly used; Guizhi Fuling Wan (GFW) was often used and combined with other herbs in the treatment of OCs.