Abstract
<p>With the purpose of finding an alternative to mitigate the damaging effect of intoxication with 2,4-D (2,4-Dichlorophenoxyacetic acid), this research aims to determine whether <em>Tabernaemontana catharinensis </em>(cobrina) increases the antioxidant capacity and/or lowers the oxidative effects generated by the exposure to this herbicide. For the above purpose, blood samples were obtained from healthy volunteers. The erythrocytes were separated, exposed to the 2,4-D and treated with different concentrations of infusions of cobrina. Tests were conducted in a water bath at 37 °C for one hour. After the analytical determinations, it was verified that, with the duration of this test, the cobrina -even containing flavonoids in its composition- increased the oxidative damages in the proteins and lipids of the erythrocytes tested. </p>
Highlights
Herbicides are agrochemicals used for controling the growth of harmful, undesirable weeds, and they are intended to significantly increase crop yields (Murussi et al, 2014)
The infusion of cobrina promoted an increase in the level of lipid peroxidation in all the concentrations tested (Figure 1)
The excess of reactive species can be responsible for a series of damaging effects, such as peroxidation of membrane lipids; attack to proteins of tissues and of membranes, enzymes, carbohydrates and deoxyribonucleic acid (DNA) by damaging membranes and causing them to lose fluidity, which can lead to the appearance of cancer as a result of the alterations in DNA; early aging, cardiovascular degenerative and neurological diseases; haemorhagic stroke and cataract, among other sicknesses (Barreiros et al, 2006; Rathee et al, 2006; Alves et al, 2010)
Summary
Herbicides are agrochemicals used for controling the growth of harmful, undesirable weeds, and they are intended to significantly increase crop yields (Murussi et al, 2014). Most of such compounds are little molecules that normally do not cause intrinsic toxic effects. Its main effects are teratogenicity, genotoxicity, neurotoxicity, immunosuppression, cytotoxicity and hepatotoxicity (Bukowska et al, 2006) This herbicide can cause alterations in the nervous system and behavior disorders (Bortolozi et al, 2003, 2004; Garcia et al, 2004), as well as nephrotoxicity in the renal proximal tubule (Saghir et al, 2013). Big profits are obtained by using this herbicide, it causes problems associated with its accumulation and leaves undesired sequels in non-targeted organisms
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